UF Drug Discovery

Instituted in 2013, the Center for Natural Products, Drug Discovery and Development (CNPD3) is housed in the Department of Medicinal Chemistry at the University of Florida College of Pharmacy and is strategically complemented by affiliated faculty from the different colleges and departments across the university.

D3 PLATFORM

D3 Platform

The chemical focus of the CNPD3 is on unique natural products, and the goal is to fully exploit the biosynthetic and therapeutic potential of untapped biodiversity for drug discovery. Candidate compounds are investigated for further development through interactive chemistry and pharmacology efforts. The center embraces all aspects of natural products research from discovery, biosynthesis and chemical synthesis, assay development, screening and target identification to drug development.

Platform Update July

CNPD3 FOCUS AND RESEARCH

CNPD3 FOCUS AND RESEARCH

Microbial Genomics & Synthetic Biology

CNPD3 FOCUS AND RESEARCH

Molecular Diversity and Screening

CNPD3 FOCUS AND RESEARCH

Molecular Pharmacology

CNPD3 FOCUS AND RESEARCH

AI-based and Structure-based Drug Design & Optimization

CNPD3 FOCUS AND RESEARCH

Synthetic Chemistry

CNPD3 Focus and Research

PROTAC & Targeted Therapeutics

CNPD3 FOCUS AND RESEARCH

Botanical Translational Science

CNPD3 FOCUS AND RESEARCH

Animal Models of Disease

A New Wave of MEDICINE

Dr. Hendrik Luesch

Answering the Call

In an ocean of possibilities, Dr. Hendrik Luesch is answering the call to make the next great drug discovery. His work takes him below the surface of the sea, where new medicines harbor hope for a healthier tomorrow.

Luesch Landing Page Play Video

CNPD3 Seminar series

CNPD3 Seminar Series | Dr. Junmei Wang

Wednesday, December 3, from 10 – 11 a.m. in C1-15 Dr. Wang’s presentation title is “Computer-Aided Drug Design in the Era of AI.”

CNPD3 Seminar Series | Dr. Jian Tang

Thursday, November 20, from 10 – 11 a.m. in C1-17 Dr. Tang’s presentation title is “Geometric Deep Learning for Protein Design.”

CNPD3 Seminar Series | Dr. Yifan Wang

Thursday, October 30, from 10 – 11 a.m. in CG-022 Dr. Wang’s presentation title is “From Structure to Catalysis: Illuminating Unusual Heme Enzymes in RiPP Biosynthesis.”

CNPD3 Seminar Series | Dr. Daniel Flaherty

Wednesday, October 22, from 10 – 11 a.m. in C1-15 Dr. Flaherty’s presentation title is “Validation of Therapeutic Targets for Antibiotics and Inflammatory Pain.”

DEPARTMENT NEWS

New medicinal chemistry space ushers in era of synergy and teamwork

A 14,500-square-foot integrated drug discovery lab will house some of UF’s medicinal chemistry faculty.

Dr. Chris McCurdy named associate editor for ACS Pharmacology & Translational Science

The appointment with ACS Pharmacology & Translational Science begins Oct. 1, 2025.

Dr. Oliver Grundmann named a fellow of the American Academy of Clinical Toxicology

He was presented with this recognition on Sept. 18 at the North American Congress of Clinical Toxicology Annual Meeting in Chicago.

Three medicinal chemistry graduate students win college awards

The UF College of Pharmacy awarded three medicinal chemistry graduate students with the college’s top honors in 2025-26.